Effect of Some Plant Extracts on The Activity of Some Enzymes Related to Metabolism

Abstract

We aimed in this research to exploit the advantages of natural compounds with their wide ranges of activities and investigate their potential to modulate multiple targets simultaneously. Indeed, the results are promising. Three metabolism-related enzymes were selected based on their activities and their significance as target for management of many ailment and ailment-related biological processes. The three assayed enzymes, α-amylase, tyrosinase and hyaluronidase, were selected on the basis explained in detail in the previous chapters. To achieve the aims of the study, 27 plants were extracted using methanol and assayed for their inhibitory in vitro activities for the mentioned enzymes. Five extracts with the most promising results were further fractionated into four fractions which also investigated for the same activities. Phytochemical screening and antioxidant activity assays were conducted using the same fractions to determine the most abundant active constituents in the respective fractions revealing many compounds classes in each fraction.