Evaluating the Level of Circulating Micro-RNAs 210 & 152 as a Clinical Bio-Marker in Pre Eclampsia

Abstract

Preeclampsia is considered one of major leading causes of maternal and fetal morbidities worldwide. The disease is almost exclusive to humans and termination of the pregnancy remains to be the only effective treatment. PE is diagnosed clinically after 20 weeks of gestation with the new onset of hypertension and proteinuria. In countries with limited access to medical care, it is estimated that PE is responsible yearly for more than 60,000 deaths worldwide. In 2013, the ACOG modified the diagnosis of PE so as to cover a wider range of previously missed cases by not putting proteinuria as an essential element in the diagnosis of PE in case of presence of signs of any end organ damage. many studies were made for early detection of PE in order to avoid its consequences through proper antenatal care. miRNAs are a class of endogenous small noncoding RNAs (about 22 nt in size), play pivotal posttranscriptional regulatory roles in normal physiological functions by targeting messenger RNAs (mRNAs) for cleavage or translational repression. miRNA contributes to the regulatory network by the complementary binding of its “seed sequence” and targets in the 30 untranslated region (30 UTR) of mRNAs.