Correlations between TIMP1, VEGF and joint magnetic resonance imaging (MRI) finding in severe haemophilia A children

Abstract

Haemophilia A is a congenital bleeding disorder due to defective production of factor FVIII with X-linked recessive inheritance. Haemophilic arthropathy is due to recurrent bleeding into joints leading to inflammation, synovitis, and subsequent destruction of cartilage and bone. Biochemical markers can provide clinically useful diagnostic tools for monitoring changes in cartilage and bone turnover in people with destructive joint disease. The current study explored biomarkers that have been identified in patients with severe haemophilia A as reflecting severity of joint damage, evaluated the applicability of these biomarkers to haemophilic arthropathy and evaluated the association between these biomarkers and compatible additive Magnetic Resonance Imaging (MRI) scores. This prospective cross-sectional study was carried out on 50 children with haemophilia A who were diagnosed and followed up in Hematology Clinic of Ain Shams University Hospitals; aged from 5-16 years, were selected randomly in the period from June 2018 to June 2019. Fifty age and sex matched normal children and adolescents were recruited from outpatient clinics.