Luteal phase support with estradiol in poor responders undergoing In Vitro Fertilization / Intra-cytoplasmic Sperm Injection using gonadotropin releasing hormone antagonist protocol: a double blind randomized controlled

Abstract

The role of progesterone supplementation as a luteal phase support in IVF cycles is well established world-wide , but the effect of luteal phase estradiol supplementation on implantation is not clearly defined. Our study was conducted at Ain Shams University maternity hospital and a private IVF center thorough the period between April 2018 and September 2019 to find out the role of estradiol with progesterone as a luteal phase support in poor responders undergoing IVF and ICSI using gonadotropin releasing hormone antagonist protocol regarding the clinical pregnancy rate. Out of 185 women assessed for eligibility for participation in the study, 170 women were eligible to participate, and were randomized within 24 hours of ovum pick-up to receive one of two different modes of luteal support. Nine women in both groups had their cycles cancelled and another 11 women were lost during follow up leaving only 150 women who completed the study.