Letrozole Prior to Misoprostol in Shortening Abortion time in the Second Trimester Abortion: A Randomized Controlled Trial

Abstract

Miscarriage is the most common complication of pregnancy, surgical evacuation is the standard management for termination of pregnancy, it is associated with anethetics and surgical risk such as uterine perforation, Asherman syndrome; Medical treatment and expectant management are alternative to surgical treatment. The most widely used regimen for induction of medical abortion involves the use of oral mifepristone200 mg followed by vaginal misoprostol 800mcg 24-48h later However, mifepristone is expensive and is only available in many countries the advantage of misoprostol is inexpensive, stable at room temperature and available. The aim of the work; this trial was performed to evaluate the effect of letrozole combined with misoprostol on induction of abortion compared with usage of misoprostol alone IN termination of second trimester abortion. This study was performed on 60women diagnosed as missed abortion at Ain Shams Maternity hospital during the period from November 2018 to June 2019; the aim was to measure the effectiveness of using 3day of letrozole 10 mg tablets followed by misoprostol to induce complete abortion, and to compare the results with the complete abortion rate using misoprostol alone.