Prevalence of Human Papillomavirus (HPV) and Distribution of Genotypes (6, 11, 16 and 18) among Egyptian Women

Abstract

uman papillomavirus (HPV) is the most common sexually transmitted infection (STI). There are many different types of HPV classified as high risk (HR) or carcinogenic and low risk (LR) responsible for benign warts. Persistent infection with high-risk (HR) human papillomavirus (HPV) is associated with premalignant lesions and cervical cancer. Despite prophylactic vaccines against HPV infections have been developed, they are not yet included in the national immunization program in Egypt. In order to measure the impact of implementing a nationwide policy for HPV prevention, this study had been done to study the prevalence and type distribution of HPV, including the most common (HR) (HPV 16 and HPV 18) and low risk (LR) types (HPV 6 and HPV 11) among Egyptian females. The aim of this study was to study prevalence of HPV and type distribution of genotypes (6, 11, 16 and 18) in cervical specimens from a group of Egyptian females attending gynaecological and family planning outpatient clinic in Ain shams Obstetrics and Gynaecology hospital. The study was conducted on 65 Egyptian women attending gynaecological and family planning outpatient clinics in Obstetrics and Gynecology Ain Shams university hospital by detection of HPV-DNA using polymerase chain reaction (PCR) and genotyping of detected HPV-DNA using multiplex PCR.