Evaluation of Antifungal Activity of Silver Nanoparticles in comparison to Antifungal Drugs against Candida Species

Abstract

Nanotechnology invades most of life fields including the medical field. But still facing many challenges to overcome harmful drawbacks like environmental pollution or hazardous side effects on human cell. Green synthesis of nanoparticles resembles a solution for emerging resistance problem of antimicrobial resistance. Silver nanoparticles are well known for their biocidal properties which include antibacterial, antifungal, antiviral, and anticancer activities. Moreover, biosynthesis of AgNps is more safe, ecofriendly & cost-effective method over physical and chemical methods. Factors contribute to a notable increase in morbidity & mortality rates related to invasive candidiasis including increased immunosuppressive states like cancer, immunosuppressive drug intake, antibiotics abuse, which leads to more incidence of opportunistic fungal infections. This study was conducted on sixty Candida isolates collected from different device associated infections submitted to Microbiology Laboratory of Ain shams university Hospitals, Egypt in the period from January to June 2018. Candida isolates were collected from 27 urine samples (45%), 15 blood samples (25%), 12 sputum samples (20%) and 6 proximal parts of central lines (10%).