STUDY OF THE DYNAMIC CHARACTERISTICS OF BIOENGINEERED BONE IN FRESH EXTRACTibN SOCKETS (Experime ntal Study) .

Abstract

This research was conducted to study the dynamic mechanical characteristics of the bioengineered alveolar bone in fresh extraction sockets, aiming to improve the mechanical properties of dental implants recipient sites. The work consisted of three stages:

I. Preparation of a porous root form scaffold.

II. Isolation and seeding of bone marrow mesenchymal stem cells onto the scaffold. III. Extraction of the first premolar of white New Zealand rabbit bilaterally and implantation of the polymer/cells construct in the left socket and the polymer tube alone in the right socket, then scarifYing the animal at two, four and six weeks and retrieving the constructs for evaluation of their dynamic mechanical characteristics using the complex modulus as an index.

The present study utilized the 50/50 PLGA biodegradable polymer to form porous root form scaffolds using the solvent casting/particulate leaching/compression molding technique. The scaffolds were then characterized using the following test: 1. Structural analysis by SEM.

2. Degradation and mass loss.

3. Dynamic compression analysis.

4. Porosity measurement.