Effect of medium -fat diets containing flaxseed, sesame seeds and their oils on non-alcoholic fatty liver disease in rats.

Abstract

The present work was conducted to study the effects of medium-fat diets containing flaxseed, sesame seeds and their oils on non-alcoholic fatty liver disease in rats. Normal male's albino rats (54) of Sprague Dawley Strain weighted 200 ± 10 g. used in this study. The rats divided into two main groups. The first main group (6 rats) fed on basal diet, as a control negative group. The second main group (48 rats) fed on high fat diet (HFD) for 6 weeks to induce non-alcoholic fatty liver disease. Non-alcoholic fatty liver disease rats were randomly assigned to eight equal subgroups: Subgroup (1): fed on high fat diet (HFD) and used as a control positive group (+ve)1. Subgroup (2): fed on medium fat diet (MFD) and used as a control positive group (+ve)2. Subgroup (3): fed on (MFD), replace (10% sheep tallow with 10% flax seeds oil). Subgroup (4): fed on (MFD), replace (10% sheep tallow with flax seeds which provided the diet with 10% oil). Subgroup (5): fed on (MFD), replace (10% sheep tallow with 10% sesame oil). Subgroup (6): fed on (MFD), replace (10% sheep tallow with sesame seeds which provided the diet with 10% oil). Subgroup (7): fed on (MFD), replace (10% sheep tallow with 5% flaxseeds oil and 5% sesame oil). Subgroup (8): fed on (MFD), replace (10% sheep tallow with sesame seeds which provided the diet with 5% oil and flax seeds which provided the diet with 5% oil).