Correlation between the prostate-specific antigen level and bone metastasis in prostate cancer. (Retrospective study)

Abstract

PCa is the most common non-cutaneous malignancy for men. PCa diagnosed by biopsy and PSA detection. BM cause severe complications, such as pathological fractures, spinal cord compression and bone pain, resulting in an overall compromised quality of life. Bone scintigraphy is commonly used for the detection and monitoring of metastatic spread of the cancer to the skeleton. The present study aimed to correlate between serum PSA level and BM in PCa patients on series of 250 patients through detecting PSA levels and BSs. In the present study Patients were stratified into two groups according to BM. Out of 250 patients 180 were localized PCa considered as group A. the remaining 70 patients were with BM considered as group B. Patients were stratified into two groups according to BM. Out of the 250 patients, 180 patients (Group A localized PCa) were with age range from 57 -92 years and a mean age of 70.65±5.99, the remaining 70 patients (Group B with metastasis) the age range was 53-88 years and a mean of 71.89±7.03 . However there was no significant difference between the mean age of the patients of both groups. The PSA levels in all patients (n=250) were ranging from 2.11 to 1404 ng/ml with mean value of 111.02 ± 238.18 while the PSA levels in patients with localized PCa (Group A , n=180) were ranging from 2.11 to 196 Ng/ml with mean value of 38.28±40.87 on the other hand in Patients with positive BS(Group B , n=70) the PSA levels were ranging from 54 to 1404 Ng/ml and a mean value of 298.07±388.69 . By comparing group A and group B there was a highly significant difference in PSA value in favor of positive BS group (p-value < 0.001)