Expression of microRNA-96 and it relationship to matrix metalloproteinase regulator- RECK in Retinoblastoma

Abstract

Retinoblastoma is a childhood malignant tumor of the retinoblasts, with prevalence rate 1:15,000–1:20,000. It may occur in non-heritable (70%–75%) or heritable (25%–30%) forms. That malignancy is due to a mutation occurred in the retinoblastoma gene (RB1), a tumor suppressor gene that is located on chromosome 13. Micro RNAs play a major role in tumorigenesis of many malignancies mainly by activating an oncogenic gene or silencing a tumor suppressor gene by targeting its mRNA for destruction. Mir- 96 was identified as an oncogenic micro-RNA in many malignancies as breast cancer, lung cancer and colon cancer. It induces malignant cells proliferative and invasive abilities by targeting many putative tumor suppressors as FOXO3a and RECK.