Predictive Value of Complete Blood Count Parameters in Placenta Accreta

Abstract

mplantation requires decidualization and vascular remodeling to provide essential nutrients and substrates to embryo. Some pregnancy complications such as early pregnancy loss, ischemic placental diseases, preeclampsia, intrauterine fetal growth restriction and premature delivery result from disturbed vascular growth in the placenta. Invasive nature of trophoblasts requires a strict control for healthy placentation. Highly invasive nature of trophoblastic tissue may result in abnormal attachments to the uterine wall and therefore trophoblasts may invade into the myometrium. The development of PAS is a complex multifactorial process. Normal placentae do not proceed beyond the inner third of the myometrium through tight spatial and temporal regulation; however, an invasive placenta proliferates and invades local structures in a similar fashion to a malignant tumour. The underlying molecular mechanisms of invasive placentation are poorly understood; proposed hypotheses include a combination of primary absence of the decidua or basal plate, abnormal maternal vascular remodelling, and excessive extravillous trophoblastic invasion.