Comparison between Salbutamol and Salbutamol with Magnesium Sulphate by nebulization in Treatment of Acute Asthma in Asthmatic Patient

Abstract

Asthma exacerbations are acute or subacute episodes of breathlessness, cough, wheezing, and chest tightness, or any combination of these symptoms. Exacerbations are associated with airways obstruction that should be documented and quantified by PEF or FEV1 measurement. Early treatment of asthma exacerbations should be the best strategy for manageasthment. MgSO4 is an agent that has been proposed as a possible additive treatment in patients with acute asthma and has been shown to be effective in patients with severe acute asthma when delivered parenterally. So, the aim of this study was to compare fast effectiveness between the nebulized salbutamol with normal Saline and salbutamol with magnesium sulphate by nebulizer in treatment of acute asthma. This two armed prospective randomized study included 60 patients admitted to intensive care unit, Ain Shams University Hospital. Patients were randomized into two groups: group A which included 30 patients on salbutamol nebulization and group B that included 30 patients on salbutamol and magnesium sulphate . Both groups received nebulization trice at intervals of 15 minutes. Salbutamol and magnesium sulphate were administered in doses of 0.5 mg and 500 mg concentration in 5 ml N.S, respectively