Synthesis and characterization of novel nanoparticles for medical purposes

Abstract

Nanotechnology has found much concern in many fields especially, the field of drug delivery due to large surface area of nanoparticles and their high ability of penetration to fulfill the medical target in a short time with low drug quantity and high efficiency. In this study, seven nanomeric compounds were synthesized inside lab as a medication for diabetes disorder. They are Zinc oxide nanoparticles (ZnONPs), Zinc oxide-Insulin nanoparticles (ZnONPs-Insulin) of ratio 1:1, Zinc oxideInsulin nanoparticles (ZnONPs-Insulin) of ratio 1:0.5, Zinc oxide-Insulin nanoparticles (ZnONPs-Insulin) of ratio 1:0.25, Curcumin-ZnO nanoparticles (CurcuminNPS-ZnONPs) of ratio 10-3 :1, Curcumin-ZnO nanoparticles (CurcuminNPS-ZnONPs) of ratio 10-4:1 and Curcumin-ZnO nanoparticles (CurcuminNPS-ZnONPS) of ratio 10-5 :1. The prepared nanomeric drugs were characterized using X-ray diffraction crystallography (XRD), High resolution transmittance microscopy (HRTEM), Fourier-transform infrared spectroscopy (FTIR), surface area and Scanning electron microscopy-energy dispersive X-ray analysis (SEM-EDX) XRD patterns proved the crystallinity of ZnONPs compounds. The presence of Insulin and Curcumin in a higher concentration in ZnONPs-Insulin of ratio 1:1 and Curcumin-ZnONPs of ratio 10-3:1 compounds led to a slight broadening in their chromatograms peaks compared with those of ZnONPs compound. For HRTEM, the images of ZnONPs-Insulin and ZnONPs-Curcumin compounds proved that the average particle size of both compounds were in the nanoscale. The images showed also, the crystalline shape of the particles which were hexagonal shape for ZnONPs and spherical shape for CurcuminNPs. EDX analysis was employed to check the purity of ZnONPs. The analysis results verified that the nanomeric compound contained Zinc and Oxygen only and was free of any interfering impurities. FTIR peaks were a great evidence on the nature of the nanomeric compounds. The average surface area and pore size of the nanomeric compounds were calculated by means of surface area measurements. Also, surface area analysis revealed the type of isotherm for the synthesized nanomeric compounds which was found to be of type IV.