STUDY OF THE HEMOSTATIC FUNCTIONS OF BLOOD IN PRE-ECLAMPSIA AND ROLE OF OXIDATIVE STRESS IN ITS PATHOGENESIS
MONA MOSTAFA MOHAMED;
Abstract
Pre-eclampsia remains a major cause of maternal and fetal ill-health. Platelet activation occurs in early pregnancy in women at risk
of developing pre-eclampsia. This disease seems to be linked to oxidative stress within the placenta and increased production of lipid peroxides.
Our purpose is to study the hemostatic functions of blood in
pre-eclampsia and the protective effect of vitamin E as an antioxidant in prevention of induced pre-eclampsia. METHODS: pre-eclampsia is induced in pregnant rats by intraperitoneal injection of nitric oxide
synthase inhibitor ( L-NAME) from the 141
day of pregnancy.% platelet
aggregation ,prothrombin time and fibrinogen level were estimated in normal pregnancy , pre-eclampsia and after treatment of these groups with vitamin E. RESULTS: Aggregation increased in pre-eclampsia which upon treatment with vitamin E returned to the normal pregnant level .CONCLUSION: vitamin E plays an important role in amelioration of the hypercoagulable state which occurs in pre-eclampsia.
of developing pre-eclampsia. This disease seems to be linked to oxidative stress within the placenta and increased production of lipid peroxides.
Our purpose is to study the hemostatic functions of blood in
pre-eclampsia and the protective effect of vitamin E as an antioxidant in prevention of induced pre-eclampsia. METHODS: pre-eclampsia is induced in pregnant rats by intraperitoneal injection of nitric oxide
synthase inhibitor ( L-NAME) from the 141
day of pregnancy.% platelet
aggregation ,prothrombin time and fibrinogen level were estimated in normal pregnancy , pre-eclampsia and after treatment of these groups with vitamin E. RESULTS: Aggregation increased in pre-eclampsia which upon treatment with vitamin E returned to the normal pregnant level .CONCLUSION: vitamin E plays an important role in amelioration of the hypercoagulable state which occurs in pre-eclampsia.
Other data
| Title | STUDY OF THE HEMOSTATIC FUNCTIONS OF BLOOD IN PRE-ECLAMPSIA AND ROLE OF OXIDATIVE STRESS IN ITS PATHOGENESIS | Other Titles | دراسة اليات إيقاف نزيف الدم من الجسم في حالات ما قبل تسمم الحمل ودور الشوادر الحرة كمسبب للمرض | Authors | MONA MOSTAFA MOHAMED | Issue Date | 2001 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| B14984.pdf | 982.96 kB | Adobe PDF | View/Open |
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