Serum Trypsinogen and Serum Lipase as Biomarkers of Exocrine Pancreatic Function in Newly Diagnosed Type1 Diabetic Children and Adolescents and Correlation with Pancreatic β Cells Function

Abstract

ype 1 diabetes mellitus is caused by deficiency of insulin secretion due to pancreatic β-cell damage. It is the most common endocrine-metabolic disorder of childhood and adolescence and with increased and variable incidence. Abnormalities of the pancreatic exocrine compartment have been described in the past decades in both anatomy and function. It is unclear whether the exocrine changes in type 1DM are related to the same genetic, immunological, and environmental events resulting in beta cell destruction or are secondary to the loss of functional β cells.