Effect of Ibuprofen and Fluoxetine on BCG-Induced Changes in Pain Perception and Pain Related Biochemical Mediators in Mice

Abstract

While depression seems to alter the experience of pain, the direction and quality of this change is unclear. Some studies found that individuals with depressed mood showed increased sensory pain intensity thresholds (i.e., decreased experimental pain sensitivity) compared to healthy controls (Dickens et al., 2003; Boettger et al, 2013). Conversely, others found that depressed individuals compared to non-depressed individuals showed decreased pain thresholds and therefore increased sensitivity to experimental pain, especially when the emotional dimension of experimental pain was evaluated (Bar et al., 2005; Klauenberg et al., 2008).