The Usage of Autologous Platelet Rich Plasma in Cases of Tibial Fracture Fixed with Interlocking nail

Abstract

Platelet-rich plasma is an autologous product that is derived from whole blood through the process of gradient density centrifugation. (PRP) therapy is a recently developed technique that uses a concentrated portion of autologous blood to try to improve and accelerate the healing of various tissues. The aim of this study was to To evaluate effectiveness of the use of platelet-rich plasma as coadjuvant for union of long bones. Study design: In this study, Comparison between two Case series studies conducted on 24 patients: 12cases with Autologous PRP injection and 12cases without Autologous PRP at Ain-Shams University Hospitals and will be arranged in randomized manner &the cases will be Simple, closed, acute mid shaft tibal fracture & the fixation will be with interlocking nail tibia in both groups. The patients will be assessed according to VAS & SMFA & RUST. Results: There are limited researches on the use of biomaterials to assist healing process. The overall results in our study revealed that there is significant better difference with PRP injection in comparison with the control group as regards healing time, pain relief & return to normal function. Conclusion: Our study suggests that with the aid of PRP, bone fractures seem to heal faster, stronger, and better than bones left untreated. Based on the results presented here, there should be an increasing interest in the use of PRP in a clinical setting.