CHILDHOOD DIABETES MELLITUS: SOME CLINICAL AND LABORATORY DIAGNOSIS

Abstract

This study was done in Assiut University Hospital in the period from January 2000 to December 2000 and included 54 children of which 29 were diabetics (IDDM) and 25 children as healthy controls. All diabetic children (29) were admitted to pediatric department, Assiut University Hospital, while controls were attending the general pediatric outpatient clinics. Of the studied diabetic children, 14 were males - (48.3%) and 15 females (51.7%) with their ages ranging from 2.5- 16

years old. Seventeen diabetic children were diabetics for less than 2 years duration and 12 were diabetics for more than 2 years duration. All studied non-diabetic controls were matched for sex and age.

The aim of this study was to detect the role of some acute phase reactants (ESR & CRP) and some markers of endothelial cell damage (vWf) in children with type I diabetes mellitus (IDDM) and their values as predictors for early diagnosis of its microvascular complications.

Beside full history and clinical examination, all studied children (patients and controls) were subjected to the following investigations: complete blood count, random blood glucose, blood urea, serum creatinine, serum electrolytes (Na+, K+ and ca++), blood gases, urine I analysis, ESR, CRP, vWf and fundus exami ation.

In this study regarding ESR, patients included in group II (diabetic children less than 2 years duration) and those in group III (diabetic children more than 2 years duration) show highly significant higher values than those of group I (non-diabetic controls).