Study of the relation between the serum insulin level and peripheral vascular state in NIDDM patients

Abstract

Patients with NIDDM commonly have endogenous hyperinsulinemia in association with the insulin resistance . High • plasma insulin levels must be considered in the pathogenesis of atherosclerosis in di betes. The prevalence of the peripheral vascular disease IS

markedly increased among individuals with diabetes mellitus. '

The aim of the present study was to find out the relation between the fasting serum insulin level in the NIDDM patients and the occurrence of peripheral vascular changes and related risk factors.

The study involved twenty type II ( NIDDM ) diabetic subjects ( on diet or oral hypoglycemic drugs ) and ten healthy individuals with comparable age and sex taken as control. Diabetic patients were divided into ten patients with hypertension and ten patients without hypertension , the age ranged between 40 to 60 years old, with duration ofDM more than 5 years. Patients with chronic liver disease and chronic renal failure were excluded.