PHARMACOKINETICAL STUDIES OF BEPHENIUM AND PYRANTEL IN LACTATING GOATS

Abstract

The maJority of anthelmintic drugs are suggested to be acting lncalh 111 the gastrointestinal tract, where the worms are found A. ::111thelmmtic drugs_ bephenium and pyrantel are used in vetertnarv field for prophylaxis and treatment of many helminthes in!'cst ttions In f tct, many of <tnthelmtntic drugs showed different degrees of intestinal absorption following its oral administration. So, the absorbed part may or may not harm the animal's body. Therefore our study was scoped on the investigation of the pharmacokinetic parameters of bephenium and pyrantel, and their eflects on some enzymatic activities in plasma of ten lactating goats after their single oral administration.

Following single oral administration of 240 mg bephenium hydroxynaphthoate/kg b. wt. in 5 lactating goats, the maximum pI as ma concentration ( 1 3.424 11g/m I) was achieved after 24 hours post administration. then decreased gradually to reach its lowest detectable level (0 152 tg/ml) at 144 hours.

The pharmacokinetic parameters of bephe111um Ill goats after a single oral dose revealed a Kab of (0 U471f\ t 0 51 abJ ( 15 28h), Cmax (14.41 11g/ml), tmax (25.16h-1 ), Kel (0 040 h- 1 ), losr0l (1745h), and Cl 101 was (3.56 ml/kg/min).