EXPRESSION OF SURVIVIN IN CHRONIC LYMPHOCYTIC LEUKEMIA
Maha Mohamed Emam Shabana;
Abstract
Chronic lymphocytic leukemia is accumulative disease which occur due to defect in programmed cell death (Apoptosis).
CLL .characterized by accumulation of lymphocytes in peripheral blood, Lymph node, spleen, liver and bone marrow
CLL is more common in old age more than 50 years old, and in males more than in females. Mostly patients with CLL paste without any symptoms and the disease discovered accidentally with routine laboratory investigations. Where CBC revealed presence of leukocytosis more than
100.000 and lymphocytosis more than 15% .With disease progression patients complaining of easily fatigability, palpitation, tachycardia, Lymph node enlargement , hepatosplenomegaly and, purperic eruptions.
CLL was classified according to Rai staging as follows: Stage 0 : Leukocytosis and lymphocytosis .
Stage 1: Lymphocytosis+ Lymph node enlargement Stage2: Lymphocytosis+ (LN +spleen +liver) enlargement Stage 3: Lymphocytosis +LN+Spleen +Liver +Anemia
Stage4:Lymphocytosis + LN + Spleen + liver + Anemia + Thrombocytopenia.
Apoptosis is an evolutionarily conserved "suicide' program present m all metazoan cells. It can be triggered by all anti-cancer drugs,
CLL .characterized by accumulation of lymphocytes in peripheral blood, Lymph node, spleen, liver and bone marrow
CLL is more common in old age more than 50 years old, and in males more than in females. Mostly patients with CLL paste without any symptoms and the disease discovered accidentally with routine laboratory investigations. Where CBC revealed presence of leukocytosis more than
100.000 and lymphocytosis more than 15% .With disease progression patients complaining of easily fatigability, palpitation, tachycardia, Lymph node enlargement , hepatosplenomegaly and, purperic eruptions.
CLL was classified according to Rai staging as follows: Stage 0 : Leukocytosis and lymphocytosis .
Stage 1: Lymphocytosis+ Lymph node enlargement Stage2: Lymphocytosis+ (LN +spleen +liver) enlargement Stage 3: Lymphocytosis +LN+Spleen +Liver +Anemia
Stage4:Lymphocytosis + LN + Spleen + liver + Anemia + Thrombocytopenia.
Apoptosis is an evolutionarily conserved "suicide' program present m all metazoan cells. It can be triggered by all anti-cancer drugs,
Other data
| Title | EXPRESSION OF SURVIVIN IN CHRONIC LYMPHOCYTIC LEUKEMIA | Other Titles | تعبير السرفيفين فى حالات سرطان الدم الليمفاوى المزمن | Authors | Maha Mohamed Emam Shabana | Issue Date | 2002 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| B13462.pdf | 971.04 kB | Adobe PDF | View/Open |
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