Comparative Study between Pre-operative Magnesium Sulphate versus Dronedarone for Prophylaxis against Atrial Fibrillation after Coronary Artery bypass grafting (CABG)

Abstract

Abstract Background: The incidence of postoperative atrial fibrillation (POAF) varies according to the type of surgery. POAF is the most commonly observed arrhythmia after coronary artery bypass grafting (CABG) and is associated with increased morbidity, mortality and prolonged hospitalization due to hemodynamic instability and thromboembolic complications. Aim of the work: to conduct a comparative study between magnesium sulphate (Mgso4) versus Dronedarone reducing incidence of atrial fibrillation after coronary artery bypass grafting. Patients and methods: This comparative study was performed in the cardiac operating room and ICU of Ain Shams University Hospitals. The study was performed on 60 patients who had undergone successful CABG. The local Ethics Committee approved of the study, and personal informed consent was taken. Methods of drug administrations, dosages were assessed. Also, Specific clinical interventions and follow-up was determined. The primary outcome was incidence of postoperative AF. Supraventricular arrhythmias other than AF (e.g. tachycardia’s and atrial flutter) and all other nonatrial arrhythmias were excluded. Results: There were no statistical difference among the both groups in terms of demographic, comorbidities, clinical and laboratory parameters. Incidence of AF was more common in 2nd group (36.7%) versus (23.33%) in first group with significant statistical difference between both groups. Conclusion: Postoperative AF is a common complication for contemporary patients undergoing CABG. The use of Mg to prevent AF after CABG was statistically significant and appears to reduce risk of atrial fibrillation a