Targeting Non-Coding RNAs with Gene Editing Tool System in Hepatocellular Carcinoma Cell Lines

Abstract

ABSTRACT Hepatocellular carcinoma (HCC) is the most common type of primary liver cancers with cirrhosis being the major risk factor for its development, it occurs usually due to HBV and HCV infection. Egypt has the highest prevalence of HCV worldwide and thus has rising rates of HCC representing a major health problem in Egypt, which highlights the urgent need for novel biomarkers for early diagnosis of HCC. HCC diagnosis depends on imaging techniques, serological tumor markers analysis and histopathological confirmation. Imaging techniques include US, CT& MRI however, their sensitivities for detection of small HCC nodules might be low while the histopathological confirmation is an invasive technique and may cause tumor seeding.