Comparison between hemodialysis and hemodiafiltration regarding effect on cognitive function

Abstract

The number of older patients with ESRD is increasing rapidly worldwide. The prevalence of CI increased from 19.8% to 23.9%. Advanced age and lower education were correlated with deterioration in cognitive function. There is increasing recognition that the ‘amyloid-cascade hypothesis’ cannot fully explain the neuronal damage in Alzheimer’s disease (AD), and that neuroinflammation plays an important role in the pathogenesis of AD and other neurodegenerative diseases. Since dialysis induces oxidative stress and chronic inflammation, it could be hypothesized that the pro-inflammatory effects of dialysis could also have a negative effect on brain amyloid deposition.