The impact of timing of renal replacement therapy on the outcome of acute kidney injury in critically ill patient: a meta-analysis

Abstract

Abstract Background: Acute kidney injury (AKI) is a common complication in the critically ill patients and associated with a substantial morbidity and mortality. Renal replacement therapy (RRT) remains the primary supportive management strategy for patients with severe AKI. However, the exact timing of initiation of RRT for better patient outcome is still debatable with conflicting data from randomized controlled trials. Thus, a systematic review and meta-analysis was performed to assess the impact of “early” versus “late” initiation of RRT. Objectives: To investigate the impact of timing of initiation of renal replacement therapy (RRT) on clinical outcomes in critically ill patients with acute kidney injury (AKI), focusing on the randomized controlled trials in this field.