Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy
Umhau, John C; Zhou, Weiyin; Thada, Shantalaxmi; Demar, James; Hussein, Nahed Mohamed; Bhattacharjee, Abesh K; Ma, Kaizong; Majchrzak-Hong, Sharon; Herscovitch, Peter; Salem, Norman; Urish, Abigail; Hibbeln, Joseph R; Cunnane, Stephen C; Rapoport, Stanley I; Hirvonen, Jussi;
Abstract
Chronic alcohol dependence has been associated with disturbed behavior, cerebral atrophy and a low plasma concentration of docosahexaenoic acid (DHA, 22∶6n-3), particularly if liver disease is present. In animal models, excessive alcohol consumption is reported to reduce brain DHA concentration, suggesting disturbed brain DHA metabolism. We hypothesized that brain DHA metabolism also is abnormal in chronic alcoholics.
Other data
| Title | Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy | Authors | Umhau, John C; Zhou, Weiyin; Thada, Shantalaxmi; Demar, James; Hussein, Nahed Mohamed ; Bhattacharjee, Abesh K; Ma, Kaizong; Majchrzak-Hong, Sharon; Herscovitch, Peter; Salem, Norman; Urish, Abigail; Hibbeln, Joseph R; Cunnane, Stephen C; Rapoport, Stanley I; Hirvonen, Jussi | Keywords | PLASMA;NEUROINFLAMMATION;RATS;CONSUMPTION;METABOLISM;DOCOSAPENTAENOIC ACID;TURNOVER;DEPRIVATION;FATTY-ACIDS;ALPHA-LINOLENIC ACID | Issue Date | 2013 | Publisher | PUBLIC LIBRARY SCIENCE | Journal | PloS one | ISSN | 1932-6203 | DOI | 10.1371/journal.pone.0075333 | PubMed ID | 24098376 | Scopus ID | 2-s2.0-84884898307 | Web of science ID | WOS:000325434500026 |
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| Umhau-2013-Brain-docosahexaenoic-acid-[dha]-in 2013.pdf | 229.36 kB | Adobe PDF | Request a copy |
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