Deficit in prepulse inhibition in mice caused by dietary n-3 fatty acid deficiency
Fedorova, Irina; Alvheim, Anita R; Hussein, Nahed Mohamed; Salem, Norman;
Abstract
Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) may be biosynthesized from a precursor alpha-linolenic acid (LNA) or obtained preformed in the diet. Dams were fed four diets with different levels of the various n-3 fatty acids during pregnancy and lactation, and their offspring were weaned to the same diets: "n-3 Deficient," containing (as % total fatty acids) 0.07% of LNA; "Low LNA" (0.4%); "High LNA" (4.8%); and a "DHA + EPA" diet, containing 0.4% of LNA, 2% DHA, and 2% EPA. Sensorimotor gating was measured by prepulse inhibition (PPI) of the acoustic startle response in C57Bl6 mice. The n-3 Deficient and Low LNA diets caused a substantial deficit in PPI compared to the DHA + EPA diet, whereas the High LNA diet induced a less pronounced, but significant reduction of PPI. These are the first data that demonstrate a deficit in sensorimotor gating in rodents caused by an inadequate amount of the n-3 fatty acids in the diet. Our results differentiate the effects of a High LNA diet from one with added EPA and DHA even though the difference in brain DHA content is only 12% between these dietary groups.
Other data
Title | Deficit in prepulse inhibition in mice caused by dietary n-3 fatty acid deficiency | Authors | Fedorova, Irina; Alvheim, Anita R; Hussein, Nahed Mohamed ; Salem, Norman | Keywords | prepulse inhibition;MEMBRANE PHOSPHOLIPID-METABOLISM;DOCOSAHEXAENOIC ACID;EICOSAPENTAENOIC ACID;SCHIZOPHRENIC-PATIENTS;PREFRONTAL CORTEX;ACOUSTIC STARTLE;IN-VIVO;REFLEX; OMEGA-3-FATTY-ACIDS;n-3 fatty acid deficiency | Issue Date | Dec-2009 | Publisher | AMER PSYCHOLOGICAL ASSOC | Journal | Behavioral neuroscience | ISSN | 0735-7044 | DOI | 10.1037/a0017446 | PubMed ID | 20001105 | Scopus ID | 2-s2.0-72249085414 | Web of science ID | WOS:000272738100007 |
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