Prevalence of common sensitizing aeroallergens in Egyptian asthmatic patients

Abstract

Background: Aeroallergens and food allergens play a key role in the pathogenesis of asthma; they are the target for future immunotherapy worldwide. Food allergens have been studied often in Egypt, but data are defective concerning the prevalent Egyptian aeroallergens that can be affected by the climatic conditions in Egypt. So, our study aimed to explore the dominant sensitizing aeroallergens in Egyptian patients with bronchial asthma. Methods: Cross-sectional study performed on 122 Egyptian asthmatic patients. Sera from all patients were examined by enzyme allegro sorbent test (EAST) method for specific IgE to a panel of 18 inhaled allergens. Results: Positive specific IgE to aeroallergens was detected in 43.44% of our patients. German cockroach (18.9%) was the most frequent sensitizing aeroallergen amongst our asthmatic patients, followed by the fungal allergens (15.57%) and house dust mites (HDMs) (13.93%). Conclusion: German cockroach, fungi, and house dust mite are the chief sensitizing aeroallergens in Egyptian asthmatic patients.