Synthesis and antitumor activity evaluation of some pyrrolone and pyridazinone heterocycles derived from 3-((2-oxo-5-(p-tolyl)furan-3(2H)-ylidene)methyl)quinolin-2(1H)-one
El-Helw, EAE; Hashem, A.I.;
Abstract
The broad spectrum of biological activity of quinoline derivatives coupled with our interest in the chemistry of furanones led us to synthesize a quinoline derivative bearing a 2(3H)-furanone scaffold. This derivative was used as a key starting material for the construction of some pyrrolone, imidazole, and pyridazinone derivatives obtained by reactions with some nitrogen nucleophiles viz. ammonium acetate, benzylamine, 1,2-diaminoethane, and hydrazine hydrate. The hydrazide obtained was condensed with 3-chlorobenzaldehyde, 1,3-diphenyl-1H-pyrazole-4-carbaldehyde, isatin, and dodecanoyl chloride to achieve the corresponding hydrazone and pyrrolone derivatives. Also, the synthesized compounds were evaluated for their in vitro antitumor activity using two cancer cell lines: breast and colon tumors. Some compounds displayed satisfactory activities.
Other data
Title | Synthesis and antitumor activity evaluation of some pyrrolone and pyridazinone heterocycles derived from 3-((2-oxo-5-(p-tolyl)furan-3(2H)-ylidene)methyl)quinolin-2(1H)-one | Authors | El-Helw, EAE ; Hashem, A.I. | Keywords | Cytotoxicity;furanone;pyridazinone;quinoline;pyrrolone;RAPID COLORIMETRIC ASSAY;2(3H)-FURANONES BEARING;CONVERSION; 2(3H)-PYRROLONES;GROWTH;SCAFFOLD;SURVIVAL;TOXICITY;BEHAVIOR | Issue Date | 2020 | Publisher | TAYLOR & FRANCIS INC | Journal | Synthetic Communications | Volume | 50 | Issue | 7 | Start page | 1046 | End page | 1055 | ISSN | 0039-7911 | DOI | 10.1080/00397911.2020.1731549 | Scopus ID | 2-s2.0-85082545254 | Web of science ID | WOS:000516744200001 |
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