Olive Leaves (Olea europaea, L.) Improve Insulinlike Growth Factor (IGF) System Implications Induced by High Fat-High Sucrose Diet

Abstract

Insulin-like growth factors system consists of insulin-like growth factors (IGF-I and –II) as ligands, IGF receptors and family of six high-affinity IGF binding proteins (IGFBPs). The aim of this study is to determine the effect of olive leaves administration either in the form of aqueous (AOLE) or ethanolic (EOLE) extracts on implications of IGF system induced by feeding on high fat-high sucrose diet. Animals were randomly separated into four groups. The first group fed on balanced diet as a control group, the second group fed on high fat-high sucrose diet, the third group fed on HF-HS diet + AOLE in oral dose of (500mg/kgbw) and the fourth group fed on HF-HS diet + EOLE in oral dose of (500mg/kgbw). Serum glucose, insulin, lipogenesis factors as well as inflammatory biomarkers and TAC, serum GH, IGF-I, IGFBP-1, IGFBP-3 were estimated. Results indicated that feeding on HF-HS diet significantly increases serum glucose, insulin and results in bad lipid profile with increased inflammatory markers and reduced TAC, in addition to disturbance in serum GH and IGF system parameters level. While, consuming either AOLE or EOLE significantly increased insulin sensitivity, and improved IGF system implications and associated inflammation, furthermore, EOLE had better effect than AOLE.