4-Phenylbutyric acid and rapamycin improved diabetic status in high fat diet/streptozotocin-induced type 2 diabetes through activation of autophagy

Gadallah, Shaimaa H, Ghanem, Hala M, Abdel-Ghaffar, Amany, Metwaly, Fatma G, Hanafy, Laila K, Ahmed, Emad,

Abstract


An accumulating body of evidence supports the role of autophagy in the pathophysiology of T2DM. Also, abnormal endoplasmic reticulum (ER) stress response that has been implicated as a cause of insulin resistance (IR) could also be affected by the autophagic status in β-cells. The present study was designed to investigate whether autophagy is regulated in T2DM as well as to investigate the modulatory effect of the ER stress inhibitor 4-phenylbutyric acid (4-PBA) and the autophagy inducer rapamycin (Rapa) on the autophagic and diabetic status using type 2 diabetic animal model with IR. Treatment of diabetic rats with either 4-PBA or Rapa improved significantly the states of hyperglycaemia and dyslipidaemia, increased the antioxidant capacity, reduced the levels of lipid peroxidation and ER stress and increased the autophagic flux. The obtained improvements were attributed mainly to the induction of autophagy with subsequent regulation of ER stress-oxidative activation and prevention of β-cell apoptosis.


Other data

Title 4-Phenylbutyric acid and rapamycin improved diabetic status in high fat diet/streptozotocin-induced type 2 diabetes through activation of autophagy
Authors Gadallah, Shaimaa H; Ghanem, Hala M; Abdel-Ghaffar, Amany; Metwaly, Fatma G; Hanafy, Laila K; Ahmed, Emad 
Keywords 4-PBA; ER stress;Insulin resistance;autophagy;rapamycin
Issue Date Jun-2021
Publisher TAYLOR & FRANCIS LTD
Journal Archives of physiology and biochemistry 
Volume 127
Issue 3
Start page 235
End page 244
ISSN 1381-3455
DOI 10.1080/13813455.2019.1628069
PubMed ID 31215250
Scopus ID 2-s2.0-85067623888
Web of science ID WOS:000475226000001

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