Synthesis and Study Antimicrobial Activities of Some Novel Tetrazole Derivatives
Maher I. Nessim; Safaa.I.elewa; Manal G. Mohamed;
Abstract
FOUR (2-phenol derivatives) were coupled with 1H-tetrazole-5-diazonium chloride to synthesize four new compounds namely 4-((1H-tetrazol-5-yl)diazenyl)-2-alkylylphenol (Ta-d). These prepared Azophenols reacted with two 4-alkoxy acids (8 and 10) to form two new series of 4-((1H-tetrazol-5-yl) diazenyl)-2-(alkyl)-phenyl-4-(octyloxy) benzoates T8a-d and 4-((1H-tetrazol-5-yl)diazenyl)-2-(alkyl)-phenyl-4-(decyloxy) benzoates T10a-d respectively. The structures of the twelve synthesized compounds were confirmed using the conventional tools of analysis, Elemental Analysis, FT-IR and 1H-NMR spectroscopy. The biological activity of the prepared compounds as anti-fungi and anti-bacteria was studied. Most of the prepared compounds possessed good antimicrobial action for Gram-positive and Gram-negative bacteria, whereas they gave no action on Aspergillus fumigatus or Candida albicans.
Other data
Title | Synthesis and Study Antimicrobial Activities of Some Novel Tetrazole Derivatives | Authors | Maher I. Nessim; Safaa.I.elewa ; Manal G. Mohamed | Keywords | Keywords;Tetrazoles;Diazotization;Phenols;1H-NMR;Biological activity | Issue Date | Feb-2018 | Publisher | National Information and Documentation Center (NIDOC) | Journal | Egypt. J. Chem | Volume | 61 | Issue | 1 | Start page | 197 | End page | 206 | Description | article |
DOI | 10.21608/EJCHEM.2018.2214.1178 |
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