Synthesis and characterization of some tetrazoles and their prospective for aerobic micro-fouling mitigation
Safaa.I.elewa;
Abstract
Two series of tetrazole derivatives of the type N-(1H-tetrazol-5-yl)-1-(aryl)methanimine
(101–106) and 1-(4-alkoxyphenyl)-N-(1H-tetrazol-5-yl)methanimine (107–111) were synthesized
and characterized via conventional tools of analysis (elemental analysis, FT-IR and 1
H NMR spec troscopy). These two synthesized series were biologically evaluated for their potentials against some
microbial biofilm causing strains (micro bio-foulants). Biological activities were evaluated by MIC
values and cell viability percentages of them. In case of compounds (107–111), 107 was the most
potent antimicrobial one, where its MIC values were 10.666667 mg/ml; 12.82222 mg/ml and
21.43666 mg/ml for Staphylococcus aureus, Escherichia coli and Candida albicans respectively,
whereas compound 106, (of group 101–106), MIC values were 16 mg/ml for all the tested microor ganisms. Viability assay showed that 107 activity percentages were 96.99456%, 92.32886% and
89.09558% against Gm +ve bacteria, Gm ve bacteria and yeast respectively, whereas 106 activity
percentages were 95.255569%, 90.204675% and 86.710956% against Gm +ve bacteria, Gm ve
bacteria and yeast respectively. Two antimicrobial mode of actions were proposed and discussed
depending on the two evaluated tetrazole groups.
(101–106) and 1-(4-alkoxyphenyl)-N-(1H-tetrazol-5-yl)methanimine (107–111) were synthesized
and characterized via conventional tools of analysis (elemental analysis, FT-IR and 1
H NMR spec troscopy). These two synthesized series were biologically evaluated for their potentials against some
microbial biofilm causing strains (micro bio-foulants). Biological activities were evaluated by MIC
values and cell viability percentages of them. In case of compounds (107–111), 107 was the most
potent antimicrobial one, where its MIC values were 10.666667 mg/ml; 12.82222 mg/ml and
21.43666 mg/ml for Staphylococcus aureus, Escherichia coli and Candida albicans respectively,
whereas compound 106, (of group 101–106), MIC values were 16 mg/ml for all the tested microor ganisms. Viability assay showed that 107 activity percentages were 96.99456%, 92.32886% and
89.09558% against Gm +ve bacteria, Gm ve bacteria and yeast respectively, whereas 106 activity
percentages were 95.255569%, 90.204675% and 86.710956% against Gm +ve bacteria, Gm ve
bacteria and yeast respectively. Two antimicrobial mode of actions were proposed and discussed
depending on the two evaluated tetrazole groups.
Other data
Title | Synthesis and characterization of some tetrazoles and their prospective for aerobic micro-fouling mitigation | Authors | Safaa.I.elewa | Keywords | Tetrazoles;Synthesis;Aerobic micro fouling;Antimicrobials;Staphylococcus aureus;Escherichia coli aureginosa | Issue Date | 2020 | Publisher | King Saud University | Journal | Arabian Journal of Chemistry | Volume | 13 | Start page | 8750 | End page | 8757 |
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