Effect of intratympanic dexamethasone administration on cisplatin-induced ototoxicity in adult guinea pigs
Shafik, Amr G.; Elkabarity, Rasha H.; Thabet, Mirahan T.; Soliman, Nevine B.; Nasrallah, Nagwa Kostandy Kalleny;
Abstract
Objective: To evaluate the effect and safety of intratympanic dexamethasone administration on cisplatin-induced ototoxicity in adult male guinea pigs and to assess the differences between early and late protection from this ototoxicity. Methods: Forty eight adult male guinea pigs were divided as follows: group I served as control group. Group II was subjected to intratympanic saline (subgroup IIa) or dexamethasone (subgroup IIb) injection. Group III was intraperitoneally injected with cisplatin. Groups IV and V were subjected first to intratympanic dexamethasone administration in both ears for 5 days starting 1 day and 1. h - respectively - before cisplatin intraperitoneal injection. Results: Dexamethasone intratympanic injection revealed similar functional and structural results compared with control. Cisplatin intraperitoneal injection resulted in a profound cochlear functional and structural damage in group III. Non-significant otoprotection resulted from intratympanic dexamethasone administration one day before cisplatin. Intratympanic dexamethasone injection 1. h before cisplatin treatment resulted in a significant preservation of the functional and structural properties of the cochlea. Conclusion: Intratympanic dexamethasone administration is a safe, easy and efficient way to protect from cisplatin ototoxicity especially when administered 1. h before cisplatin treatment. © 2012 Elsevier Ireland Ltd.
Other data
Title | Effect of intratympanic dexamethasone administration on cisplatin-induced ototoxicity in adult guinea pigs | Authors | Shafik, Amr G.; Elkabarity, Rasha H.; Thabet, Mirahan T.; Soliman, Nevine B.; Nasrallah, Nagwa Kostandy Kalleny | Keywords | Cisplatin;Ototoxicity;Guinea pigs;Dexamethasone | Issue Date | 1-Jan-2013 | Journal | Auris Nasus Larynx | Volume | 40 | Issue | 1 | Start page | 51 | End page | 60 | ISSN | 03858146 | DOI | 10.1016/j.anl.2012.05.010 | PubMed ID | 22884636 | Scopus ID | 2-s2.0-84873080565 |
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