Kinin B1 receptors contributes to acute pain following minor surgery in humans
Hamza, May; Wang, Xiao-Min; Adam, Albert; Brahim, Jaime S; Rowan, Janet S; Carmona, Gilberto N; Dionne, Raymond A;
Abstract
Kinins play an important role in regulation of pain and hyperalgesia after tissue injury and inflammation by activating two types of G-protein-coupled receptors, the kinin B1 and B2 receptors. It is generally accepted that the B2 receptor is constitutively expressed, whereas the B1 receptor is induced in response to inflammation. However, little is known about the regulatory effects of kinin receptors on the onset of acute inflammation and inflammatory pain in humans. The present study investigated the changes in gene expression of kinin receptors and the levels of their endogenous ligands at an early time point following tissue injury and their relation to clinical pain, as well as the effect of COX-inhibition on their expression levels.
Other data
Title | Kinin B1 receptors contributes to acute pain following minor surgery in humans | Authors | Hamza, May ; Wang, Xiao-Min; Adam, Albert; Brahim, Jaime S; Rowan, Janet S; Carmona, Gilberto N; Dionne, Raymond A | Keywords | NF-KAPPA-B;NECROSIS-FACTOR-ALPHA;ISOLATED RAT SKIN;INDUCED NOCICEPTOR SENSITIZATION;PROSTAGLANDIN E-2 RELEASE;SPINAL-CORD-INJURY;GENE-EXPRESSION;BRADYKININ RECEPTOR;UP-REGULATION;HUMAN LUNG FIBROBLASTS | Issue Date | 13-Feb-2010 | Publisher | BIOMED CENTRAL LTD | Journal | Molecular pain | ISSN | 1744-8069 1744-8069 |
DOI | 10.1186/1744-8069-6-12 | PubMed ID | 20152050 | Scopus ID | 2-s2.0-77949431334 | Web of science ID | WOS:000275468200001 |
Attached Files
File | Description | Size | Format | Existing users please Login |
---|---|---|---|---|
Molecular pain.pdf | 728.46 kB | Adobe PDF | Request a copy |
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.