Effects of taurine and/or ginseng and their mixture on lipid profile and some parameters indicative of myocardial status in streptozotocin-diabetic rats
Afaf Abbass Sayed Saleh;
Abstract
This represented study aims to evaluate the protective effects of two natural antioxi-dants, taurine and/or ginseng and their mixture on lipid profile and some parameters indicative
of myocardial status in streptozotocin-diabetic rats.
Adult male albino rats (Sprague Dawley strain) were divided into five groups, a control and four
experimental groups; each of them contains five rats. The experimental animals were injected (i.p)
with 40 mg/kg body weight of streptozotocin (STZ) daily for 2 successive days to induce diabetes.
The first group of diabetic rats was considered as a diabetic group and left without treatment. The
second group was injected i.p with 500 mg/kg body weight of taurine daily for one month and
served as diabetic plus taurine group. In the third group, ginseng was given orally at a dose of
400 mg/kg body weight daily for the same previous period. The last group received both taurine
and ginseng treatments at the aforementioned doses and through the same routes for one month.
The results indicated that the administration of taurine or ginseng showed a remarkable ameliora-tion in glucose, glycosylated hemoglobin (HbA1C), insulin and free T3
levels. The maximum amelio-ration in the level of glucose, HbA1C, insulin and free T3occurred in diabetic rats that received the
mixture of taurine andginseng.Additionally, treatment of diabetic ratswith twoantioxidants induced
a significant reduction in serum cholesterol, triglycerides and low density lipoprotein levels. The anti-oxidants also displayed a significant decrease in the activities of cardiac enzymes, aspartate amino-transferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH) and the levels of serum
endothelin-1 with a significant elevation in the levels of serum total nitric oxide (TNO) in the diabetic
animals group.The results suggest that acombination treatment between taurine andginsengmight rep-resent the treatment of patientswith cardiovascular disease (CVD) which is related todiabetic disorder.
of myocardial status in streptozotocin-diabetic rats.
Adult male albino rats (Sprague Dawley strain) were divided into five groups, a control and four
experimental groups; each of them contains five rats. The experimental animals were injected (i.p)
with 40 mg/kg body weight of streptozotocin (STZ) daily for 2 successive days to induce diabetes.
The first group of diabetic rats was considered as a diabetic group and left without treatment. The
second group was injected i.p with 500 mg/kg body weight of taurine daily for one month and
served as diabetic plus taurine group. In the third group, ginseng was given orally at a dose of
400 mg/kg body weight daily for the same previous period. The last group received both taurine
and ginseng treatments at the aforementioned doses and through the same routes for one month.
The results indicated that the administration of taurine or ginseng showed a remarkable ameliora-tion in glucose, glycosylated hemoglobin (HbA1C), insulin and free T3
levels. The maximum amelio-ration in the level of glucose, HbA1C, insulin and free T3occurred in diabetic rats that received the
mixture of taurine andginseng.Additionally, treatment of diabetic ratswith twoantioxidants induced
a significant reduction in serum cholesterol, triglycerides and low density lipoprotein levels. The anti-oxidants also displayed a significant decrease in the activities of cardiac enzymes, aspartate amino-transferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH) and the levels of serum
endothelin-1 with a significant elevation in the levels of serum total nitric oxide (TNO) in the diabetic
animals group.The results suggest that acombination treatment between taurine andginsengmight rep-resent the treatment of patientswith cardiovascular disease (CVD) which is related todiabetic disorder.
Other data
| Title | Effects of taurine and/or ginseng and their mixture on lipid profile and some parameters indicative of myocardial status in streptozotocin-diabetic rats | Authors | Afaf Abbass Sayed Saleh | Keywords | Streptozotocin-diabetic rats; Taurine; Ginseng; Lipid profile; Myocardial status | Issue Date | 12-Oct-2012 | Publisher | ELSEVIER B. V | Journal | The Journal of Basic & Applied Zoology | DOI | 10.1016/j.jobaz.2011.12.001 |
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