Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa
Ebada, Sherif; Linh, Mai Hoang; Longeon, Arlette; de Voogd, Nicole J; Durieu, Emilie; Meijer, Laurent; Bourguet-Kondracki, Marie-Lise; Müller, Werner E G; Proksch, Peter; Singab A.;
Abstract
Chemical investigation of methanolic extracts of the two Indonesian marine sponges Stylissa massa and Stylissa flabelliformis yielded 25 bromopyrrole alkaloids including 2 new metabolites. The structures of all isolated compounds were unambiguously elucidated based on extensive 1D and 2D NMR, LR-MS and HR-MS analyses. All isolated compounds were assayed for their antiproliferative and protein kinase inhibitory activities. Several of the tested compounds revealed selective activity(ies) which suggested preliminary SARs of the isolated bromopyrrole alkaloids.
Other data
| Title | Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa | Authors | Ebada, Sherif ; Linh, Mai Hoang; Longeon, Arlette; de Voogd, Nicole J; Durieu, Emilie; Meijer, Laurent; Bourguet-Kondracki, Marie-Lise; Müller, Werner E G; Proksch, Peter; Singab A. | Keywords | antiproliferative; bromopyrrole alkaloids; neurodegenerative disorders; protein kinase | Issue Date | Feb-2015 | Publisher | TAYLOR & FRANCIS LTD | Journal | Natural product research | ISSN | 1478-6419 | DOI | 10.1080/14786419.2014.947496 | PubMed ID | 25116895 | Scopus ID | 2-s2.0-84919836152 | Web of science ID | WOS:000346586100005 |
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