A new cytotoxic steroid from co-fermentation of two marine alga-derived micro-organisms
Ebada, Sherif; Fischer, Thomas; Klaßen, Sarah; Hamacher, Alexandra; Roth, Yoen Ok; Kassack, Matthias U; Roth, Eckhard H;
Abstract
Bioactivity-guided chemical investigation of a co-culture of marine-derived micro-organisms has yielded one new steroid, 7β-hydroxycholesterol-1β-carboxylic acid (1) with an unprecedented carboxylic acid group at C-1, together with three known steroidal metabolites (2-4). The chemical structures and stereochemistry of the isolated compounds were unambiguously determined based on extensive 1D, 2D NMR and HR-ESI-MS measurements. The isolated compounds were assessed for their cytotoxic activity against four different human tumour cell lines K562 (leukaemia), HCT116 (colon), A2780 (ovary) and its cisplatin-resistant mutant (A2780 CisR), and they revealed moderate activities with IC50 values ranging from 10.0 to 100.0 μM.
Other data
| Title | A new cytotoxic steroid from co-fermentation of two marine alga-derived micro-organisms | Authors | Ebada, Sherif ; Fischer, Thomas; Klaßen, Sarah; Hamacher, Alexandra; Roth, Yoen Ok; Kassack, Matthias U; Roth, Eckhard H | Keywords | Aspergillus; antiproliferative; co-fermentation; marine micro-organisms; steroids | Issue Date | 2014 | Publisher | TAYLOR & FRANCIS LTD | Journal | Natural product research | ISSN | 1478-6419 | DOI | 10.1080/14786419.2014.895730 | PubMed ID | 24620785 | Scopus ID | 2-s2.0-84905388908 | Web of science ID | WOS:000340267000004 |
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