Uses of 1-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]-thiophen-2-yl)-3- dodecanoylthiourea as a Building Block in the Synthesis of Fused Pyrimidine and Thiazine Systems
Magdy Mohamed Hemdan; Heba Kamal Abd El-Mawgoud;
Abstract
The reaction of lauroyl isothiocyanate and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile was used to synthesize the title compound 2. Compound 2 could serve as the main building block in the synthesis of many target heterocyclic systems. Various fused pyrimidines were synthesized in the reactions of compound 2 with sodium ethoxide, hydrazine hydrate, phenyl hydrazine, ethyl carbazate, thiourea, and/or 2-aminothiophenol. The structures of the synthesized compounds were confirmed by microanalytical and spectral data.
Other data
Title | Uses of 1-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]-thiophen-2-yl)-3- dodecanoylthiourea as a Building Block in the Synthesis of Fused Pyrimidine and Thiazine Systems | Authors | Magdy Mohamed Hemdan; Heba Kamal Abd El-Mawgoud | Keywords | lauroyl isothiocyanate;fused system;pyrimidine derivative;2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile | Issue Date | Jun-2015 | Publisher | © 2015 The Pharmaceutical Society of Japan | Journal | Chem. Pharm. Bull. | Volume | 63 | Issue | 6 | Start page | 450 | End page | 456 | DOI | 10.1248/CPB.C15-00047 |
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