Utility of Lauroyl Isothiocyanate as a Scaffold in the Synthesis of Some Novel Pyrimidine Derivatives and Their Antimicrobial Assessment
Heba Kamal Abd El-Mawgoud; Magdy Mohamed Hemdan;
Abstract
The reaction of lauroyl isothiocyanate 1 with enaminonitrile derivative 2 furnished N-(6-cyano-3,4-diphenylthieno[2,3-c]pyridazin-5-yl-carbamothioyl)dodecanamide 3, which was used as precursor for the synthesis of novel heterocyclic systems. Polyfunctional pyrimidine and fused pyrimidine derivatives were obtained by the cyclization of compound 3 under different basic conditions as well as its reactions with thiourea, o-aminothiophenol, hydrazine hydrate, phenyl hydrazine, ethyl phenyl acetate or ethyl benzoyl acetate. The structures of the new compounds were confirmed by microanalytical and spectral properties. The synthesised compounds were tested in-vitro for their antimicrobial activity and showed congruent results against most of the tested microorganisms compared to the standard drugs Gentamycin and Ketoconazol.
Other data
Title | Utility of Lauroyl Isothiocyanate as a Scaffold in the Synthesis of Some Novel Pyrimidine Derivatives and Their Antimicrobial Assessment | Authors | Heba Kamal Abd El-Mawgoud ; Magdy Mohamed Hemdan | Keywords | lauroyl isothiocyanate;antimicrobial screening;fused pyrimidine;pyrimidine;enaminonitrile | Issue Date | Nov-2018 | Publisher | © 2018 The Pharmaceutical Society of Japan | Journal | Chemical and Pharmaceutical Bulletin | Volume | 66 | Issue | 11 | Start page | 1072 | End page | 1077 | DOI | 10.1248/CPB.C18-00595 |
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