Uses of 2-(Thiophene-2-carbonylcarbamothioylthio)acetic Acid as a Good Synthon for Construction of Some New Thiazole and Annulated Thiazole Derivatives
Heba Kamal Abd El-Mawgoud; Saad Ramadan Atta-Allah; Magdy Mohamed Hemdan;
Abstract
The reaction of thiophene-2-carbonyl isothiocyanate 2 with thioglycolic acid gave 2-(thiophene-2-carbonylcarbamothioylthio)acetic acid 3. Compound 3 was subjected to some selected reactions with sulphuric acid as well as benzaldehyde, piperonal and isatin under different reaction conditions. The products obtained were new derivatives of thiazole and annulated thiazole derivatives bearing thiophene moiety in some cases. The structures of the new synthesized compounds were confirmed on the basis of their microanalytical and spectral properties. Some compounds were tested for their antimicrobial activity against six selected microorganisms using the standard antibacterial Gentamycin and antifungal Ketoconazole as references.
Other data
Title | Uses of 2-(Thiophene-2-carbonylcarbamothioylthio)acetic Acid as a Good Synthon for Construction of Some New Thiazole and Annulated Thiazole Derivatives | Authors | Heba Kamal Abd El-Mawgoud ; Saad Ramadan Atta-Allah; Magdy Mohamed Hemdan | Keywords | thiophene-2-carbonyl isothiocyanate;antimicrobial activity;indole;fused thiazole;thiazole | Issue Date | Oct-2018 | Publisher | © 2018 The Pharmaceutical Society of Japan | Journal | Chemical and Pharmaceutical Bulletin | Volume | 66 | Issue | 10 | Start page | 992 | End page | 998 | DOI | 10.1248/CPB.C18-00482 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.