Synthesis and Antimicrobial Evaluation of Thieno[2,3-d]-pyrimidine, Thieno [2 ', 3 ':4,5]pyrimido [1,2-a][1,3,5]triazine, Thieno[2,3-d]-1,3-thiazine and 1,2,4- Triazole Systems
Magdy Mohamed Hemdan; Heba Kamal Abd El-Mawgoud;
Abstract
The reaction of lauroyl isothiocyanate with ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate gave ethyl 2-(3-dodecanoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 3. Compound 3 could serve as a main building block in synthesis of the target heterocyclic systems like thieno[2,3-d]pyrimidine, thieno[2′,3′:4,5]pyrimido[1,2-a][1,3,5]triazine, thieno[2,3-d]-1,3-thiazine and 1,2,4-triazole systems attached to the lauryl group. The structures of the synthesized target heterocyclic compounds were confirmed by microanalytical and spectral data. The antimicrobial activity of some of the synthesized compounds was tested.
Other data
Title | Synthesis and Antimicrobial Evaluation of Thieno[2,3-d]-pyrimidine, Thieno [2 ', 3 ':4,5]pyrimido [1,2-a][1,3,5]triazine, Thieno[2,3-d]-1,3-thiazine and 1,2,4- Triazole Systems | Authors | Magdy Mohamed Hemdan; Heba Kamal Abd El-Mawgoud | Keywords | fused 1,3-thiazine;lauroyl isothiocyanate;fused 1,3-diazine;2-amino-4,5,6,7- tetrahydrobenzo[b]thiophene-3-carboxylate;1,2,4-triazole | Issue Date | Oct-2015 | Publisher | © 2015 The Pharmaceutical Society of Japan | Journal | Chemical and Pharmaceutical Bulletin | Volume | 63 | Issue | 10 | Start page | 812 | End page | 818 | DOI | 10.1248/CPB.C15-00463 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.