Normal Growth despite Combined Pituitary Hormone Deficiency
El Kholy, Mohamed; Perin, Laurence; Abi Habid, Walid; Thibaud, Nathalie; Bozzola, Mauro; Rossignol, Sylvie; Leneuve, Patricia; Godeau, François; Chantot-Bastaraud, Sandra; Netchine, Irène; Le Bouc, Yves; Elsedfy, Heba;
Abstract
The paradox of normal growth despite a lack of growth hormone (GH) is an unexplained phenomenon described in some pathological (sellar, suprasellar, and hypothalamic disorders) and overgrowth syndromes. It has been suggested that the paradoxical growth is due to other GH variants, GH-like moieties, prolactin, insulin, insulin-like growth factors (IGFs), and unidentified serum factors or growth mechanisms. The objective of this study was to determine the mechanism underlying this normal growth without GH.
Other data
| Title | Normal Growth despite Combined Pituitary Hormone Deficiency | Authors | El Kholy, Mohamed ; Perin, Laurence; Abi Habid, Walid; Thibaud, Nathalie; Bozzola, Mauro; Rossignol, Sylvie; Leneuve, Patricia; Godeau, François; Chantot-Bastaraud, Sandra; Netchine, Irène; Le Bouc, Yves; Elsedfy, Heba | Keywords | Combined pituitary hormone deficiency;Growth;IGF/IGFBP-3 molar ratio;Insulin-like growth factors | Issue Date | 2019 | Publisher | KARGER | Journal | Hormone research in paediatrics | Volume | 92 | Issue | 2 | Start page | 133 | End page | 142 | ISSN | 1663-2818 | DOI | 10.1159/000499318 | PubMed ID | 31022718 | Scopus ID | 2-s2.0-85064942402 | Web of science ID | WOS:000507907900008 |
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