Review and Recommendations on Management of Adult Female Thalassemia Patients with Hypogonadism based on Literature Review and Experience of ICET-A Network Specialists
De Sanctis, V; Soliman, AT; Albu, A; Al Jaouni, S; Anastasi, S; Bisconte, MG; Canatan, D; Christou, S; Daar, S; Di Maio, S; El Kholy, M; Khater, D; Elshinawy, M; Kilinc, Y; Mattei, R; Mosli, HH; Quota, A; Roberti, MG; Sobti, P; AL Yaarubi, S; Canpisi, S; Kattamis, C; Elsedfy, Heba;
Abstract
Multi-transfused thalassemia major (TM) patients frequently develop severe endocrine complications, mainly due to iron overload, anemia, and chronic liver disease, which require prompt diagnosis, treatment and follow-up by specialists. The most common endocrine complication documented is hypogonadotropic hypogonadism which increases with age and associated comorbidities. It is thus important for physicians to have a clear understanding of the pathophysiology and management of this disorder. Also to be aware of the side effects, contraindications and monitoring of sex steroid therapy. In this paper, practical ICET-A recommendations for the management of hypogonadism in adult females with TM are addressed.
Other data
Title | Review and Recommendations on Management of Adult Female Thalassemia Patients with Hypogonadism based on Literature Review and Experience of ICET-A Network Specialists | Authors | De Sanctis, V; Soliman, AT; Albu, A; Al Jaouni, S; Anastasi, S; Bisconte, MG; Canatan, D; Christou, S; Daar, S; Di Maio, S; El Kholy, M ; Khater, D; Elshinawy, M; Kilinc, Y; Mattei, R; Mosli, HH; Quota, A; Roberti, MG; Sobti, P; AL Yaarubi, S; Canpisi, S; Kattamis, C; Elsedfy, Heba | Keywords | Thalassemia; hypogonadism; hormone replacement therapy; benefits and disadvantages; HORMONE REPLACEMENT THERAPY; BETA-THALASSEMIA; THROMBOEMBOLIC EVENTS; POSTMENOPAUSAL WOMEN; HEPATITIS-C; RISK; CONTRACEPTIVES; COMPLICATIONS; MENOPAUSE | Issue Date | 2017 | Publisher | MATTIOLI 1885 | Journal | MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES | ISSN | 2035-3006 | DOI | 10.4084/MJHID.2017.001 | PubMed ID | 28101307 | Scopus ID | 2-s2.0-85010223805 | Web of science ID | WOS:000395534500001 |
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