Does Insulin Like Growth Factor-1 (IGF-1) Deficiency Have a "Protective" Role in the Development of Diabetic Retinopathy in Thalassamia Major Patients?
De Sanctis, V; Incorvaia, C; Soliman, AT; Candini, G; Pepe, A; Kattamis, C; Soliman, NA; mohamed, elkholy; Elsedfy, Heba;
Abstract
Both insulin and IGF-1 have been implicated in the control of retinal endothelial cell growth, neovascularization and diabetic retinopathy. Recent findings have established an essential role for IGF-1 in angiogenesis and demonstrated a new target for control of retinopathy that explains why diabetic retinopathy initially increases with the onset of insulin treatment.
Other data
| Title | Does Insulin Like Growth Factor-1 (IGF-1) Deficiency Have a "Protective" Role in the Development of Diabetic Retinopathy in Thalassamia Major Patients? | Authors | De Sanctis, V; Incorvaia, C; Soliman, AT; Candini, G; Pepe, A; Kattamis, C; Soliman, NA; mohamed, elkholy ; Elsedfy, Heba | Keywords | ENDOTHELIAL-CELLS; GENE-EXPRESSION; PREVALENCE; QUANTIFICATION; NEPHROPATHY; MELLITUS; REGION; VIVO | Issue Date | 1-Jan-2015 | Publisher | PAGEPRESS PUBL | Journal | Mediterranean Journal of Hematology and Infectious Diseases | Volume | 7 | ISSN | 2035-3006 | DOI | 10.4084/MJHID.2015.038 | PubMed ID | 26075045 | Scopus ID | 2-s2.0-84942694252 | Web of science ID | WOS:000357399300002 |
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