Sustainable antimicrobial modified chitosan and its nanoparticles hydrogels: Synthesis and characterization
Hassan, Hemat; Nadia G. Kandile; ismail, mansoura; Marwa ElS. Ahmed;
Abstract
The target of the present study is the development of sustainable chitosan and chitosan nanoparticles-based heterocyclic
compound hydrogels with antimicrobial properties. Sustainable antimicrobial new modified chitosan
hydrogel (CS-3) was synthesized by the reaction of chitosan (CS) with 2-([4-[(1, 3-dioxoisoindolin-2-ylimino)
methyl] phenyl] methyleneamino) isoindoline-1, 3-dione (3) via ring opening of cyclic imide moiety in compound
(3). However, the modified chitosan nanoparticles hydrogel (CS-3 NPs) were prepared in-situ by an
ionotropic gelation technique using sodium tripolyphosphate (TPP) as the cross-linking agent. The prepared
hydrogels were characterized by FTIR, SEM, TEM, TGA, DSC and elemental analysis. The hydrogels were tested
versus eight pathogenic strains of Gram +ve and Gram −ve bacteria and two fungi. The results revealed that
hydrogels (CS-3) and (CS-3 NPs) showed higher antimicrobial activities than virgin (CS) and (CS-NPs). However,
hydrogel (CS-3 NPs) showed the highestMinimal Inhibitory Concentration (MIC) andMinimal Bactericidal Concentration
(MBC) especiallywith Gram+ve bacteria (S. pyogenes) at 19.5 and 39 μg/ml compared to the standard
antibiotic Ciprofloxacin at 19 and 38 μg/ml respectively.
compound hydrogels with antimicrobial properties. Sustainable antimicrobial new modified chitosan
hydrogel (CS-3) was synthesized by the reaction of chitosan (CS) with 2-([4-[(1, 3-dioxoisoindolin-2-ylimino)
methyl] phenyl] methyleneamino) isoindoline-1, 3-dione (3) via ring opening of cyclic imide moiety in compound
(3). However, the modified chitosan nanoparticles hydrogel (CS-3 NPs) were prepared in-situ by an
ionotropic gelation technique using sodium tripolyphosphate (TPP) as the cross-linking agent. The prepared
hydrogels were characterized by FTIR, SEM, TEM, TGA, DSC and elemental analysis. The hydrogels were tested
versus eight pathogenic strains of Gram +ve and Gram −ve bacteria and two fungi. The results revealed that
hydrogels (CS-3) and (CS-3 NPs) showed higher antimicrobial activities than virgin (CS) and (CS-NPs). However,
hydrogel (CS-3 NPs) showed the highestMinimal Inhibitory Concentration (MIC) andMinimal Bactericidal Concentration
(MBC) especiallywith Gram+ve bacteria (S. pyogenes) at 19.5 and 39 μg/ml compared to the standard
antibiotic Ciprofloxacin at 19 and 38 μg/ml respectively.
Other data
Title | Sustainable antimicrobial modified chitosan and its nanoparticles hydrogels: Synthesis and characterization | Other Titles | Sustainable antimicrobial modified chitosan and its nanoparticles hydrogels: Synthesis and characterization | Authors | Hassan, Hemat ; Nadia G. Kandile; ismail, mansoura ; Marwa ElS. Ahmed | Keywords | Chitosan;Heterocyclic compound;Antimicrobial activity;Nanoparticles | Issue Date | Aug-2020 | Journal | International Journal of Biological Macromolecules | Volume | 162 | Start page | 1388 | End page | 1397 | DOI | https://doi.org/10.1016/j.ijbiomac.2020.08.048 |
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