An efficient approach for the synthesis and antimicrobial evaluation of some new benzocoumarins and related compounds
Mohamed Hussein Hussein Moustafa Hekal; Abu El-Azm, Fatma; Samir, SS;
Abstract
A convenient synthetic approach for pharmaceutically important benzocoumarin-based heterocyclic compounds has been studied. β-enaminonitrile has been used for the synthesis of a broad diversity of new benzocoumarins and related compounds over different reaction steps. Various synthetic approaches were used in this research for synthesis of heterocyclic systems such as acid-catalyzed hydrolysis, decarboxylation, deamination, ring opening and ring closure. The molecular structures of the newly synthesized derivatives were established by elemental analyses and spectral data (IR, 1H-NMR, and 13C-NMR). Some of the newly synthesized compounds were explored for their antimicrobial activities.
Other data
Title | An efficient approach for the synthesis and antimicrobial evaluation of some new benzocoumarins and related compounds | Authors | Mohamed Hussein Hussein Moustafa Hekal ; Abu El-Azm, Fatma ; Samir, SS | Keywords | Benzo[f]coumarin;β -enaminonitrile;deamination;keto-enol tautomerism;nitrogen nucleophiles;ring opening of benzo[f]coumarin;ONE-POT SYNTHESIS;DERIVATIVES;COUMARIN;WARFARIN;DESIGN;OSTHOL | Issue Date | 2021 | Publisher | TAYLOR & FRANCIS INC | Journal | Synthetic Communications | Volume | 5 | Issue | 14 | Start page | 2175 | End page | 2186 | ISSN | 0039-7911 | DOI | 10.1080/00397911.2021.1925917 | Scopus ID | 2-s2.0-85106300404 | Web of science ID | WOS:000650523000001 |
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