Click synthesis of new 7-chloroquinoline derivatives by using ultrasound irradiation and evaluation of their biological activity
Aboelnaga, A; El-Sayed, Taghreed;
Abstract
This study describes the click synthesis of new 7-chloroquinoline derivatives by using ultrasound irradiation and evaluation of their activity as antimicrobial, antimalarial and the anticancer. All the compounds show moderate antimalarial activity with IC50< 100 μM, six of them showed high antimalarial activity (2, 3, 4, 6, 8 and 9) with IC50< 50 μM. The most active 7- chloroquinoline derivative is a compound (9). Also, the newly synthesized compounds were screened for their antitumor activity towards three lines of cancer cells, MCF-7 (human breast cancer), HCT-116 (colon carcinoma) and Hela (Cervical carcinoma) cell lines. Compounds (3) and (9) exerted the highest activity on all cell lines and showed special selectivity toward MCF-7 cells and the antibacterial screening data showed moderate to good inhibition zone (12.5 ± 0.63–23.8 ± 1.5) towards all the tested compounds. Elucidation of the structures of these new pure compounds was based on, IR,1H NMR,13C NMR, MS and their elemental analysis. (Image presented).
Other data
Title | Click synthesis of new 7-chloroquinoline derivatives by using ultrasound irradiation and evaluation of their biological activity | Authors | Aboelnaga, A; El-Sayed, Taghreed | Keywords | SONOCHEMISTRY;Ultrasonic radiation;7-chloroquinoline;click chemistry;antimalarial activity;and cytotoxicity;PLASMODIUM-FALCIPARUM;IN-VITRO;ANTIMALARIAL ACTIVITY;POTENTIAL ANTIMALARIAL;MALARIAL PARASITE;AGENTS;REGIOSELECTIVITY;RESISTANCE;HETEROCYCLES | Issue Date | 2018 | Publisher | TAYLOR & FRANCIS LTD | Journal | GREEN CHEMISTRY LETTERS AND REVIEWS | ISSN | 1751-8253 | DOI | 10.1080/17518253.2018.1473505 | Scopus ID | 2-s2.0-85053449912 | Web of science ID | WOS:000432633500002 |
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