Ball Milling Assisted Solvent and Catalyst Free Synthesis of Benzimidazoles and Their Derivatives
El-Sayed, Taghreed; Aboelnaga, Asmaa; Hagar, Mohamed;
Abstract
Benzoic acid and o-phenylenediamine efficiently reacted under the green solvent-free Ball Milling method. Several reaction parameters were investigated such as rotation frequency; milling balls weight and milling time. The optimum reaction condition was milling with 56.6 g weight of balls at 20 Hz frequency for one hour milling time. The study was extended for synthesis of a series of benzimidazol-2-one or benzimidazol-2-thione using different aldehydes; carboxylic acids; urea; thiourea or ammonium thiocyanate with o-phenylenediamine. Moreover; the alkylation of benzimidazolone or benzimidazolthione using ethyl chloroacetate was also studied.
Other data
| Title | Ball Milling Assisted Solvent and Catalyst Free Synthesis of Benzimidazoles and Their Derivatives | Authors | El-Sayed, Taghreed ; Aboelnaga, Asmaa ; Hagar, Mohamed | Keywords | Ball Milling;mechanochemistry;green chemistry;combinatorial chemistry;benzimidazoles | Issue Date | 24-Aug-2016 | Publisher | MDPI | Journal | Molecules (Basel, Switzerland) | ISSN | 1420-3049 | DOI | 10.3390/molecules21091111 | PubMed ID | 27563861 | Scopus ID | 2-s2.0-84987910744 | Web of science ID | WOS:000385479800008 |
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